Do noninherited maternal antigens (NIMA) enhance renal graft survival?

Maternal Antigens Induces CD4 Developmental Exposure to Noninherited

Major and Minor Histocompatibility Antigens to Non-Inherited Maternal Antigens (NIMA)

Immunological reactivity results from differences between the transplant host and donor for cell surface determinants known as histocompatibility antigens. Histocompatibility antigens that provoke the most severe transplant reactions are encoded by a series of genes that reside in a discrete chromosomal region termed the major histocompatibility complex (MHC) (Amos 1968). Genes of the human leu...

Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice.

In mice and humans, the immunologic effects of developmental exposure to noninherited maternal antigens (NIMAs) are quite variable. This heterogeneity likely reflects differences in the relative levels of NIMA-specific T regulatory (T(R)) versus T effector (T(E)) cells. We hypothesized that maintenance of NIMA-specific T(R) cells in the adult requires continuous exposure to maternal cells and a...

Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development.

Rheumatoid arthritis (RA) is a complex genetic disorder in which the HLA-region contributes most to the genetic risk. HLA-DRB1-molecules containing the amino acid sequence DERAA (i.e., HLA-DRB1*0103, *0402, *1102, *1103, *1301, *1302, and *1304) are associated with protection from RA. It has been proposed that not only inherited but also noninherited HLA-antigens from the mother (NIMA) can infl...

Reexposure of cord blood to noninherited maternal HLA antigens improves transplant outcome in hematological malignancies.

Cord blood (CB) hematopoietic stem cell transplantation can be successful even if donor and recipient are not fully matched for human leukocyte antigens (HLA). This may result from tolerance-inducing events during pregnancy but to date this concept has not been tested in CB transplantation. Hence we analyzed the impact of fetal exposure to noninherited maternal antigens (NIMA) of the HLA-A, -B ...